Test portfolio

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Biomeostasis’s test portfolio allows you to evaluate the efficacy and/or safety of your compounds on the major components of energy homeostasis affected in eating and metabolic disorders.

 

 

 

 

 

 

 

  

 

 

 

 

 

 

 

 

 

Energy expenditure & body composition

 

With totally non-invasive methods, we can explore for you the ability of your compounds to modify energy expenditure and body composition of rodent models. Our tests include for example:

 

>> EE-01: Indirect calorimetry

>> EE-02: Body composition

>> EE-03: Body temperature

>> EE-06: Locomotor activity


 

For more information, feel free to contact us.

 

 

Glucose and lipid homeostasis

 

Glucose and lipid homeostasis are both key regulations affected during metabolic disorders such as obesity, diabetes, dyslipidemia and overweight. We can provide you with some standard tests in order to evaluate the efficacy of your compounds to improve these disorders:

 

>> GLH-01: OGTT

>> GLH-03: Insulin tolerance test

>> GLH-06: Intestinal digestion of lipids (in vitro)

>> GLH-07: Standard biomarkers (LDL-C, HDL-C, HbA1c…)

 

 

For more information, feel free to contact us.

 

 

 

Neurobiological control of energy homeostasis

 

Energy homeostasis depends in part on neurobiological processes involving emblematic brain areas. Thanks to our great expertise in neurobiology and neurosurgery, we can explore for you the central mechanisms of action of your compounds:

 

>> NEU-01: Cerebral treatments in vigil animals

>> NEU-05: Cerebral biomarkers


 

For more information, feel free to contact us.

 

 

Gastrointestinal function

 

Gastrointestinal function is an another component involved in nutritional behavior control, and is affected during metabolic disorders especially leading to a dysregulation of nutrients absorption. Our tests include simple, fast and large-scale assays for a rapid approach of your compounds effects on gastrointestinal function as well as more in-depth approaches for a complete characterization of these effects:

 

>> G-01: Total transit

>> G-03: Intestinal transit

>> G-08: Caco-2 model (in vitro)

 

For more information, feel free to contact us.

 

 

Cardiovascular function

 

As a first-step approach, we can assess the beneficial or side effects of your compounds on cardiovascular system in rodents

Our tests include, but are not limited to:

 

>> CV-01: ECG

>> CV-02: Blood pressure (NIBP)

>> CV-03: Isolated heart

 

For more information, feel free to contact us.

 

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